The recommended regimen for medical abortion
The prescribed and recommended dosage by most medical experts for MTP abortion kit is – 1 Mifepristone tablet [200 mg] and 4 Misoprostol tablets [400 mcg].
The regimen includes –
- Take 1 Mifepristone pill orally.
- Wait for 24 – 48 hours
- Take 4 pills of Misoprostol. Put them in the cheek pouches and keep them for 30 minutes. Swallow them after.
Are other doses of Mifepristone [anti-progesterone] possible?
Both anti-progestogens and prostaglandin-like Mifepristone/Misoprostol pill are capable of causing a pregnancy termination. However, the efficacy rate is very low when they are taken singularly. Therefore, to find the best regimen, the idea is to find dosage for both medications which is low on dosage, high in effectiveness but low in side effects as well. In many parts of the globe, cost considerations are just as important.
In many countries, Mifepristone is availed in 600 mg dosage. But, nowhere do studies mention to require more than 200 mg for medical termination of pregnancy.
Some medical texts also prescribe repeated dosages of Mifepristone in 25 mg dosages over three days amounting up to 125-150 mg. This regimen is widely used in China and has been proven to effectively end the pregnancy under 49 days of gestation. However, for the purpose of service delivery and convenience for patients, this regimen is not optimum.
While in other studies 50 mg of Mifepristone is shown to be insufficient with other types of prostaglandin analogue like the gemeprost.
Therefore, according to studies up to date, recommend the regimen mentioned above.